Can an Autoimmune Disease Be the Cause of Peyronie’s Disease?

Does Peyronie’s Disease Start?

Peyronie’s Disease begins with inflammation in the penis that can cause scarring. This build-up of scar tissue is called plaque. The plaque accumulates inside the tissues of the tunica albuginea; a thick, elastic membrane inside the penis. As the plaque builds inside the penis, the penis will begin to curve or bend, causing painful erections.

Many experts believe that Peyronie’s Disease may be the result of an autoimmune disorder, in which the body’s immune system attacks the body’s own cells and organs. In cases of Peyronie’s Disease, the immune system would be attacking health tissue in the penis believing it is protecting the organ from bacteria, viruses, or other potentially harmful foreign substances. As a result, this causes inflammation in the penis that leads to scarring. While there is no solid evidence to prove this theory, understanding the ways autoimmune disorders work and what we know about Peyronie’s Disease, research suggests there appears to be a link.


Studies have shown that men who have certain connective tissue and autoimmune disorders may have a higher probability of developing Peyronie’s Disease. Connective tissue disorders associated with Peyronie’s Disease include:
•plantar fasciitis- thickening tissue on the bottom of the foot that connects the heel bone to the toes and creates the arch of the foot
•scleroderma- abnormal growth of the connective tissue, causing it to get thick and hard.
•Dupuytren’s disease- abnormal cordlike thickening across the palm of the hand

Approximately 15% of men who suffer from Dupuytren’s disease develop Peyronie’s Disease.

Autoimmune disorders associated with Peyronie’s Disease include:

•Systemic lupus erythematosus-inflammation and damage to various body tissues
•Sjogren’s syndrome- inflammation and damage to the glands that make tears and saliva
•Behcet’s syndrome- inflammation of the blood vessels

Much more research is needed in this area in part thanks to the increase in diagnosed autoimmune diseases over the last few decades. What medical experts do know is that some of the autoimmune diseases associated with Peyronie’s Disease can affect connective tissues so some researchers strongly suggest there is a link between the two. Our medical team at the Indianapolis Men’s Clinic follow this research closely and keep patients abreast of new studies and findings.

For now, if you are a male suffering from an autoimmune disorder or connective tissue disorder, watch for the signs of Peyronie’s Disease.

If you notice changes in your erection, pain during an erection, or feel what could be the formation of plaque in the tunica albuginea consult with a men’s sexual health professional. The men’s health doctors at the Indianapolis Men’s Clinic can help you detect Peyronie’s Disease. Our physicians specialize in treating Peyronie’s Disease, and offer the most effective, safest, FDA approved treatment options available for effectively treating this disorder. We also offer treatment options for erectile dysfunction, low testosterone and premature ejaculation. We treat patients living in Indianapolis, IN, Bloomington, IN, Muncie, IN, Lafayette, IN, Noblesville, IN, and surrounding areas. To schedule your confidential appointment please call (317) 689-0252 or schedule an appointment online.